Center for Biomedical Imaging at Stanford  

CBIS Report
January 11, 2011

In This Issue:

2011 3rd Annual Symposium

Scan Centers: Ask the Experts

Faculty Profile: Butrus Khuri-Yakub, Sam Gambhir


CBIS logo

2011 3rd Annual Symposium

The date for the 3rd Annual CBIS Symposium in 2011 has now been set, and all the main speakers have been lined up. Please note the date: March 29, 2011. Please also note the location: The Li Ka Shing Center for Learning and Knowledge, the brand new educational facilty in the School of Medicine. We are proud to announce our keynote speaker is Dr. Rod Pettigrew, Director of the NIBIB.

We are now accepting abstract applications for our poster session and symposium presentations. Please visit the event website for continually updated details and to download an application. The submission deadline is February 15, 2011.

Free registration is coming soon, as well. Please register so we can plan accordingly, and make this the best event possible for everyone involved.

Full information on the event is updated regularly on the event website at:



Scan Centers: Ask the Experts

What are the services provided? What are the specifics of the imaging methods? You ask the experts.

Richard M. Lucas Center for Imaging
Service: Whole Body Magnetic Resonance Imaging at 1.5T and 3T (

Date: Tues January 25, 2 pm
Where: Go to the front lobby of the Lucas Center at 1201 Welch Road. The front lobby is on the ground level by the firelane turnaround.
Contact: Anne Sawyer

Small Animal Imaging Center
Service: Small Animal Imaging with 7T MRI, Ultrasound, PET, SPECT, CT, Optical (

Date: Tuesday February 8, 2 pm
Where: go to the basement of Clark, and then follow the signs to the imaging lab (South wing, S040).
Contact: Tim Doyle

Stanford Radiology 3D and Quantitative Imaging Lab
Service: Image Rendering and Image Analysis (

Date: Tuesday February 15, 2 pm
Where: Clark Center S344
Contact: Sandy Napel

Neuroscience Microscopy Service (NMS)
Service: Microscopy: Two-photon, confocal, fluorescence, image analysis (

Date: Tuesday February 22, 2:00 pm
Where: NMS is now located in the basement of SIM1 (Lokey Stem Cell Building), suite G0901. Take the elevator to the basement, then take your first two right turns.
Contact: Andrew Olson

Khuri-Yakub headshot Gambhir headshot

Butrus Khuri-Yakub

Sam Gambhir

CBIS Collaborative Work Advances Photoacoustic Imaging in Early Disease Detection

By converting infrared laser light into high-frequency ultrasound waves, photoacoustic imaging (PAI) allows the visualization of body structures at an extraordinary depth and resolution, offering new possibilities for early disease detection. CBIS members Butrus T. Khuri-Yakub, PhD, professor of electrical engineering and deputy director of the Edward L. Ginzton Laboratory, and Sanjiv “Sam” Gambhir, MD, PhD, Virginia & D.K. Ludwig Professor of Radiology & Bioengineering; professor of materials science & engineering, director of the Molecular Imaging Program at Stanford (MIPS); chief of the Nuclear Medicine Division; and head of the Canary Center at Stanford for Cancer Early Detection, are developing new applications of PAI for cancer imaging.

To optimize PAI, Dr. Khuri-Yakub and his team, the Ultrasonics Group, are improving the capacitive micromachined ultrasound transducers (CMUTs), which allow 3D images to be acquired using large area, two-dimensional arrays. The Khuri-Yakub Group has optimized the static and the dynamic behavior of viscoelastic-polymer-coated CMUTs for medical imaging and therapeutic ultrasound, providing protective insulation while maintaining high performance. In addition, the group has developed application specific integrated circuits (ASICs) that interface the CMUTs to RF electronics as well as beam forming for 3D real-time imaging. The Khuri-Yakub Ultrasonics Group also investigates real-time, forward looking, volumetric ultrasound imaging; micromachined chemical/biological sensors; non-destructive evaluation; acoustic microscopy; and therapeutic ultrasound. To learn more, please access their website at .

Developing the new field of PAI molecular imaging, Dr. Gambhir and his laboratory have created and tested several types of photoacoustic imaging agents in small animals including those based on gold nanoparticles. To further enhance the molecular imaging applications of photoacoustic imaging, they have designed one of the first smart probes reported for PAI that provides a target-dependent photoacoustic signal and enables visualization of the signal only in the presence of the target of interest. The lab has also developed multimodality nanoparticles that merge the advantages of MRI, Raman, and photoacoustics. The development of a trans-rectal photoacoustic probe based on CMUTs is also near completion and will be tested in prostate cancer patients in 2011. Other key MIPS research areas include the synthesis and validation of radiolabeled and fluorescent molecular probes for molecular imaging; the development of molecular imaging instrumentation for living subjects; the design of molecular imaging approaches/assays for interrogating cellular events in living subjects; the creation of software tools for visualization and analysis of molecular imaging data; and the merger of therapeutics and imaging strategies for improved patient management. The MIPS website ( contains more detailed information about their research.


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