The biodistribution of [18F]FTC-146 is highly specific to regions of known high S1R expression. PET/MRI scans show increased specific uptake of [18F]FTC-146 in the neuroma in the sciatic nerve of a rat neuropathic pain model (Spared Nerve Injury (SNI)). The increased uptake in PET/MRI images has been verified by ex vivo autoradiography of the sciatic nerves (Figs. A and B, respectively). Control and sham models do not show any increase in tracer uptake in the nerves.
Vinicio A. de Jesus, MD
Project: Optical Coherence Tomography as a Novel Tool in the Evaluation of the Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is a disorder characterized by loss and narrowing of small distal arteries resulting in abnormal elevation of pulmonary pressures. Currently, the gold standard for PAH diagnosis is right heart catheterization (RHC) but this technique does not provide any information on the state of vascular wall pathology. We propose that use of optical coherence tomography (OCT), an innovative intravascular imaging technique recently approved by the FDA for use in the assessment of coronary artery disease (CAD), is a safe diagnostic procedure that can be done as part of the RHC in PAH patients to characterize the extent of vascular remodeling in pulmonary vessels at diagnosis and following institution of therapy. We believe that this information could be used alongside established clinical and hemodynamic predictors when determining a patient's chances for progression, survival and response to therapy at any given point in the natural history of the disease.
Audrey Ellerbee, PhD
Project: 3D Localization of Cell Positioning for Early Prediction of Embryonic Development to Blastocyst Stage
Despite known adverse outcomes, the low success rate of post-implantation human embryos drives the current clinical practice of transferring multiple embryos during in vitro fertilization (IVF) procedures. Recently, it has been shown that automated 2D image analysis can successfully predict progression of the zygote to the blastocyst stage with > 93% sensitivity and specificity, which could lead to better and more informed IVF outcomes. The goal of this project is to use optical coherence microscopy to investigate embryonic development in 3D, with the hope that additional information provided by the 3D images will produce more salient markers for blastocyst development and extend knowledge of the process of human development.
Other Key Personnel:
Tom Baer; Barry Behr, PhD, HCLD;